US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on April 8 for "Compositions and methods for the treatment of carboxyhemoglobinemia" (Maryland, Pennsylvania Inventors)

ALEXANDRIA, Va., April 9 -- United States Patent no. 12,269,866, issued on April 8, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"Compositions and methods for the treatment of carboxyhemoglobinemia" was invented by Mark T. Gladwin (Baltimore) and Jesus Tejero Bravo (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with ex...