US Patent Issued to UNIVERSITY OF MASSACHUSETTS on Dec. 23 for "Modified HIV-1 proviral vectors with enhanced dendritic cell transduction efficiencies comprising the JRFL envelope" (Massachusetts Inventor)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,503,499, issued on Dec. 23, was assigned to UNIVERSITY OF MASSACHUSETTS (Westborough, Mass.).

"Modified HIV-1 proviral vectors with enhanced dendritic cell transduction efficiencies comprising the JRFL envelope" was invented by Jeremy Luban (Newton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments thereof in a mammalian subject. The methods comprise administering a virus or virus-like particle to a mammal comprising heterologous immune cells and isolating a population of immunoglobulin-producing ...