US Patent Issued to University of Massachusetts on Dec. 2 for "Bicistronic AAV vectors encoding hexosaminidase alpha and beta-subunits and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,518, issued on Dec. 2, was assigned to University of Massachusetts (Westborough, Mass.).

"Bicistronic AAV vectors encoding hexosaminidase alpha and beta-subunits and uses thereof" was invented by Miguel Sena Esteves (Westford, Mass.) and Diane Golebiowski (Billerica, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to bicistronic AAV nucleic acid constructs comprising a transgene encoding hexosaminidase A (HEXA) and hexosaminidase (HEXB) proteins. In some embodiments, the disclosure provides methods for treating or preventing lysosomal storage disorders, such as Tay-Sachs disease and Sandhoff disease, using bicist...