US Patent Issued to UNIVERSITY OF IOWA RESEARCH FOUNDATION on Aug. 5 for "Digital nuclease detection compositions and methods" (Iowa Inventor)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,591, issued on Aug. 5, was assigned to UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa).

"Digital nuclease detection compositions and methods" was invented by James O. McNamara (Iowa City, Iowa).

According to the abstract* released by the U.S. Patent & Trademark Office: "In certain embodiments, the present invention provides a detection composition comprising a picodroplet comprising (a) an aqueous solution, and (b) a substrate probe comprising (i) an oligonucleotide of 2 to 75 nucleotides in length, (ii) a fluorophore operably linked to the oligonucleotide, and (iii) a quencher operably linked to the oligonucleotide. As used herein, the term "picodroplet" comprises a liqu...