ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,384,767, issued on Aug. 12, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"Probe for detection of cathepsin activity" was invented by Lina Cui (Gainesville, Fla.) and Kelton Schleyer (Gainesville, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "In this vein, we present CTLAP, a fluorogenic probe that is rapidly activated by CTL and displays good selectivity over CTB and CTV, the closest competing analytes for CTL activity probes. CTLAP exhibits intrinsically low background fluorescence, which we attribute to the notably low quantum yield measured for the probe. CTLAP demonstrates markedly higher turn-on ratios (...