US Patent Issued to University of Cincinnati on March 11 for "Method of making prodrug for sustained and controlled release" (Ohio Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,246,069, issued on March 11, was assigned to University of Cincinnati (Cincinnati).

"Method of making prodrug for sustained and controlled release" was invented by Joo-Youp Lee (Cincinnati), Edward Merino (Cincinnati), Vishnu Sriram (Cincinnati) and Mina Jafari (Cincinnati).

According to the abstract* released by the U.S. Patent & Trademark Office: "A novel ROS-responsive prodrug is provided. The prodrug utilizes a unique modified oxalate linker conjugated to 4-aminophenol, which can enhance the reaction kinetics for intracellular ROS within tumor tissues while keeping the modified oxalate backbone stable with amide bond under very low ROS level."

The patent was filed on March 26, ...