US Patent Issued to University of British Columbia on Sept. 30 for "Peptide directed protein knockdown" (Canadian Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,428,456, issued on Sept. 30, was assigned to University of British Columbia (Vancouver, Canada).

"Peptide directed protein knockdown" was invented by Yu Tian Wang (Vancouver, Canada), Xuelai Fan (Vancouver, Canada) and Jack Wuyang Jin (Vancouver, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogeno...