ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,628, issued on Oct. 21, was assigned to Uniqure IP B.V. (Amsterdam).
"Further improved AAV vectors produced in insect cells" was invented by Jacek Lubelski (Amsterdam), Sebastiaan Bosma (Amsterdam), Harald Peter Albert Petry (Amsterdam) and Wilhelmus Theodorus Johannes Maria Christ Hermens (Amsterdam).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is a non-AT...