ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,496, issued on Dec. 2, was assigned to uniQure IP B.V. (Amsterdam).
"AAV vectors produced by insect cells comprising Rep52 and Rep78 coding sequences with differential codon biases" was invented by Andrew Christian Bakker (Almere, Netherlands) and Wilhelmus Theodorus Johannes Maria Christiaan Hermens (Almere, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the...