US Patent Issued to UCB BIOPHARMA on June 10 for "De novo antibody design" (British Inventors)

ALEXANDRIA, Va., June 18 -- United States Patent no. 12,327,613, issued on June 10, was assigned to UCB BIOPHARMA SRL (Brussels).

"De novo antibody design" was invented by Terence Seward Baker (Slough, Great Britain), Xiaofeng Liu (Slough, Great Britain), Jiye Shi (Slough, Great Britain) and Richard David Taylor (Slough, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "Computer-implemented methods of designing an antibody that will bind to a target epitope are disclosed. In one arrangement, the method comprises identifying one or more hotspot residues that will each bind to a corresponding one of one or more hotspot sites on the target epitope. Candidate antibody structures are selected from a da...