US Patent Issued to uBriGene (MA) Biosciences on Dec. 9 for "Engineered sgRNA design and preparation method" (Chinese Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,397, issued on Dec. 9, was assigned to uBriGene (MA) Biosciences Inc. (Dover, Del.).

"Engineered sgRNA design and preparation method" was invented by Xiulian Sun (Jiangsu, China), Sheng Zhao (Jiangsu, China) and Xiangyang Zhang (Jiangsu, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a DNA-targeting RNA comprising a single-guide RNA (sgRNA) and a ribonucleotide sequence rich in adenine ribonucleotide, and its use in gene editing, and a method for improving the efficiency of sgRNA-mediated gene editing, comprising a step of adding a ribonucleotide sequence rich in adenine ribonucleotide at 3' end of the sgRNA."

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