US Patent Issued to Tune Therapeutics on March 18 for "Compositions, systems, and methods for regulation of hepatitis B virus through targeted gene repression" (North Carolina, Washington Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,692, issued on March 18, was assigned to Tune Therapeutics Inc. (Seattle).

"Compositions, systems, and methods for regulation of hepatitis B virus through targeted gene repression" was invented by Brian Cosgrove (Durham, N.C.), Kendra Congdon (Durham, N.C.), Jason Dean (Seattle), Veronica Gough (Durham, N.C.), Joshua B. Black (Durham, N.C.) and Britta Jones (Durham, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reductio...