US Patent Issued to Trustees of Tufts College on Feb. 4 for "FAP-activated proteasome inhibitors for treating solid tumors" (Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 12,214,047, issued on Feb. 4, was assigned to Trustees of Tufts College (Medford, Mass.).

"FAP-activated proteasome inhibitors for treating solid tumors" was invented by William W. Bachovchin (Cambridge, Mass.), Hung-sen Lai (Andover, Mass.) and Sarah E. Poplawski (Belmont, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in tr...