US Patent Issued to Trustees of Boston College on Oct. 7 for "Genetically encoded tyrosine sulfation of proteins in eukaryotes" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,327, issued on Oct. 7, was assigned to Trustees of Boston College (Chestnut Hill, Morocco).

"Genetically encoded tyrosine sulfation of proteins in eukaryotes" was invented by Abhishek Chatterjee (Lexington, Mass.) and James S. Italia (Charlestown, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "An engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells is described herein. This platform enables recombinant expression of eukaryotic proteins homogeneously sulfated at chosen sites."

The patent was filed on April 23, 2020, under Application No. 17/594...