US Patent Issued to TriLink BioTechnologies on March 25 for "Compositions and methods for synthesizing 5'-capped RNAs" (California Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,369, issued on March 25, was assigned to TriLink BioTechnologies LLC (San Diego).

"Compositions and methods for synthesizing 5'-capped RNAs" was invented by Richard I. Hogrefe (San Diego), Alexandre Lebedev (San Diego), Anton P. McCaffrey (San Diego) and Dongwon Shin (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and compositions for synthesizing 5'Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2'Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, "n" can be any integer from 0 to 4 and "m"...