ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,401, issued on Jan. 13, was assigned to TREXAPHARM PTY LTD (Brisbane, Australia).

"Compositions comprising flumazenil and naltrexone and methods for use thereof" was invented by Lee Eric Rodne (Eaton Hill, Australia), Daniel John Zanardo (Ashgrove, Australia) and Julian Chick (Northcote, Australia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to pharmaceutical compositions comprising flumazenil and naltrexone, especially compositions comprising low-dose flumazenil and low-dose naltrexone. The present invention also relates to methods for the use of a combination of flumazenil and naltrexone in the treatment of depressi...