ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,465,601, issued on Nov. 11, was assigned to TRANSTHERA SCIENCES (NANJING) INC. (Jiangsu, China).
"Uses of phosphodiesterase inhibitors" was invented by Zejuan Sheng (Jiangsu, China) and Frank Wu (Jiangsu, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are uses of a compound represented by general formula (I) and pharmaceutically acceptable salts, isomers and deuterated compounds thereof in the preparation of a medicine for treating heart failure diseases. Experiments prove that the compound can improve the heart function of rats with heart failure, reverse myocardial remodeling caused by heart failure, and reduce fibrosis in the marginal...