ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,538, issued on Sept. 23, was assigned to TRANSLATE BIO INC. (Lexington, Mass.).
"Quantitative assessment for cap efficiency of messenger RNA" was invented by Frank Derosa (Lexington, Mass.), Anusha Dias (Lexington, Mass.) and Michael Heartlein (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro. In some embodiments, methods according to the present invention comprise providing an mRNA sample containing capped and uncapped mRNA, providing a cap specific binding substance under conditions that permit...