ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,453,759, issued on Oct. 28, was assigned to TRANSLATE BIO INC. (Waltham, Mass.).
"Di-thioester cationic lipids" was invented by Shrirang Karve (Lexington, Mass.) and Frank DeRosa (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, in part, di-thioester cationic lipid compounds or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or ...