US Patent Issued to Translate Bio on March 11 for "Ribonucleic acids with 4'-thio-modified nucleotides and related methods" (Massachusetts Inventors)

ALEXANDRIA, Va., March 12 -- United States Patent no. 12,247,046, issued on March 11, was assigned to Translate Bio Inc. (Cambridge, Mass.).

"Ribonucleic acids with 4'-thio-modified nucleotides and related methods" was invented by Frank DeRosa (Waltham, Mass.) and Michael Heartlein (Waltham, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are messenger RNA molecules and related compositions incorporating a 4'-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4'-thio modified mRNA provides for enhanced stability an...