ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,005, issued on June 17, was assigned to TRANSLATE BIO INC. (Waltham, Mass.).
"Ionizable cationic lipids" was invented by Frank DeRosa (Waltham, Mass.), Braydon Charles Guild (Waltham, Mass.) and Michael Heartlein (Waltham, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as ha...