ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,666, issued on Dec. 30, was assigned to TRANSLATE BIO INC. (Waltham, Mass.).
"MRNA therapy for phenylketonuria" was invented by Frank DeRosa (Lexington, Mass.), Anusha Dias (Lexington, Mass.) and Michael Heartlein (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, among other things, methods of treating phenylketonuria (PKU), including administering to a subject in need of treatment a composition comprising an mRNA encoding phenylalanine hydroxylase (PAH) at an effective dose and an administration interval such that at least one symptom or feature of PKU is reduced in intensity, severity, or frequency or...