ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,583, issued on Dec. 16, was assigned to TOYO SEIKAN GROUP HOLDINGS LTD. (Tokyo).

"Adherent cell culture substrate, culture vessel, cell detachment method, and method for producing adherent cell culture substrate" was invented by Osamu Koseki (Kanagawa, Japan), Satoshi Tanaka (Kanagawa, Japan), Yosuke Matsuoka (Kanagawa, Japan) and Takaharu Nishiyama (Kanagawa, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "An adherent cell culture substrate, which is a sheet-shaped substrate used for producing a culture vessel for adherent cells, includes a groove including a crest-shaped portion and a valley-shaped portion on one surface side of the substrate...