US Patent Issued to Tongji University, Board of Regents of the University of Nebraska on Jan. 27 for "Methods and compositions for selective generation of dopaminergic precursors" (Chinese, American Inventors)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,534,740, issued on Jan. 27, was assigned to Tongji University (Shanghai) and Board of Regents of the University of Nebraska (Lincoln, Neb.).

"Methods and compositions for selective generation of dopaminergic precursors" was invented by Jialin Zheng (Shanghai) and Changhai Tian (Omaha, Neb.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides methods of transdifferentiating a somatic cell, e.g., a fibroblast, to an induced dopaminergic precursor cell (iDP) in vitro. The methods include ectopically expressing genes of (1) one or both of Brn2 and Brn4, or a variant thereof, (2) Sox2, or a variant thereof, and (3) one or both of Fox...