ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,420, issued on March 25, was assigned to TigaTX Inc. (Boston).
"Engineered IGA antibodies and methods of use" was invented by Jeanette Henrica Wilhelmina Leusen (Utrecht, Netherlands), Johannes Gerardus Maria Evers (Utrecht, Netherlands) and Geert Jan Van Tetering (Utrecht, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are engineered antibodies that comprise a modified IgA2 heavy chain constant region, pharmaceutical compositions, and methods of use. The engineered antibodies described herein comprise one or more amino acid substitutions or deletions in a constant region of an IgA2 domain that modify naturally occurring...