ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,184, issued on July 15, was assigned to Thoeris GmbH (Vienna).
"Use of glutamine synthetase for treating hyperammonemia" was invented by Tamara Nicolson (London).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the use of glutamine synthetase as a protein therapy (such as enzyme replacement protein therapy) for the treatment of hyperammonemia. In particular the invention relates to the systemic administration of glutamine synthetase. The glutamine synthetase may be provided in conjugated or fusion form, to increase its half-life in the circulation. Also provided is a pharmaceutical composition comprising glutamine synth...