US Patent Issued to The Wistar Institute on Aug. 19 for "Adenoviral vectors comprising partial deletions of E3" (Pennsylvania Inventors)

ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,391,959, issued on Aug. 19, was assigned to The Wistar Institute (Philadelphia).

"Adenoviral vectors comprising partial deletions of E3" was invented by Hildegund C. J. Ertl (Villanova, Pa.) and Xiang Yang Zhou (North Wales, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective deletion of E3 and are particularly useful for preparation of vaccines development and for gene therapy using toxic transgene products that result in vector instability that occurs when the entire E3 domain is deleted."

The p...