US Patent Issued to The University of North Carolina at Chapel Hill on Sept. 9 for "Synthetic liver-tropic adeno-associated virus capsids and uses thereof" (North Carolina Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,441, issued on Sept. 9, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Synthetic liver-tropic adeno-associated virus capsids and uses thereof" was invented by Xiao Xiao (Chapel Hill, N.C.), Juan Li (Chapel Hill, N.C.), Bin Xiao (Chapel Hill, N.C.) and Zhenhua Yuan (Chapel Hill, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to synthetic adeno-associated virus capsids targeted to the liver and virus vectors comprising the same. The invention further relates to methods of using the vectors to target the liver and provide liver-specific expression, as well as transduce human primary hep...