US Patent Issued to The University of North Carolina at Chapel Hill on Nov. 11 for "Methods for using dual glycan binding AAV vectors" (North Carolina Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,860, issued on Nov. 11, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Methods for using dual glycan binding AAV vectors" was invented by Aravind Asokan (Chapel Hill, N.C.) and Richard Samulski (Hillsborough, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are methods for delivery of a nucleic acid to a subject for treatment of a disease, comprising administering a modified adeno-associated virus (AAV) vector that contains a therapeutic transgene comprising the nucleic acid in expressible form, further comprising a modified AAV2 capsid protein, comprising amino acid substitutions that intro...