US Patent Issued to The University of North Carolina at Chapel Hill on March 25 for "Optimized CLN1 genes and expression cassettes and their use" (Texas Inventor)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,257,322, issued on March 25, was assigned to The University of North Carolina at Chapel Hill (Chapel Hill, N.C.).

"Optimized CLN1 genes and expression cassettes and their use" was invented by Steven Gray (Southlake, Texas).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention relates to polynucleotides comprising a nucleotide sequence encoding a PPT1 polypeptide or a fragment thereof, vectors (viral or non-viral vectors) comprising the same, and methods of using the same for delivery of the open reading frame to a cell or a subject and to treat infantile neuronal lipofuscinosis (infantile Batten disease). The polynucleotides comprise an optimize...