US Patent Issued to THE UNIVERSITY OF CHICAGO on Sept. 30 for "Compositions and methods related to kethoxal derivatives" (Illinois Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,428,666, issued on Sept. 30, was assigned to THE UNIVERSITY OF CHICAGO (Chicago).

"Compositions and methods related to kethoxal derivatives" was invented by Chuan He (Chicago), Xiaocheng Weng (Chicago) and Tong Wu (Chicago).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments are directed to N3-kethoxal reagents and derivatives thereof, and related methods that allow fast and reversible labeling of single-stranded nucleic acids in live cells. By way of example, one aspect is directed to a process for reversible labeling of single-stranded guanine bases in live cells, which results in an effective in vivo method for transcriptome-wide RNA secondary...