ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 12,216,121, issued on Feb. 4, was assigned to THE UNIVERSITY OF CHICAGO (Chicago).

"Methods and compositions for spacial and temporal measurement of catalytic activity" was invented by Yamuna Krishnan (Chicago), Krishna Dan (Chicago), Aneesh T. Veetil (Chicago) and Kasturi Chakraborty (Chicago).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are nucleic acid molecules and complexes useful for spatiotemporally mapping intra-endosmal thiol disulphide exchange. Aspects of the disclosure relate to a composition comprising a first nucleic acid conjugated to a normalization moiety; and a second nucleic acid conjugated to a catalytic substrate; wher...