US Patent Issued to The United States of America, as represented by the Secretary, Department of Health and Human Services on Nov. 25 for "T cell receptors recognizing R175H or Y220C mutation in P53" (Maryland, Texas, Virginia Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,902, issued on Nov. 25, was assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Md.).

"T cell receptors recognizing R175H or Y220C mutation in P53" was invented by Drew C. Deniger (Houston), Parisa Malekzadeh (Norfolk, Va.) and Steven A. Rosenberg (Potomac, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R175H or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceu...