US Patent Issued to The Trustees of the University of Pennsylvania on Jan. 27 for "Compositions and methods for targeting mutant RAS" (Pennsylvania Inventors)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,533,409, issued on Jan. 27, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Compositions and methods for targeting mutant RAS" was invented by Adham Bear (Philadelphia), Robert Vonderheide (Merion Station, Pa.), Gerald Linette (Gladwyne, Pa.) and Beatriz Carreno (Gladwyne, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention relates to compositions and methods of treating cancer associated with mutant RAS. In certain aspects, the invention relates to antigenic RAS peptide fragments and T-cell receptors that bind to specific mutant RAS peptide fragments in the context of specific HLA types."

The patent was fi...