US Patent Issued to The Trustees of the University of Pennsylvania on Dec. 9 for "Scalable purification method for AAV9" (Pennsylvania Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,385, issued on Dec. 9, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Scalable purification method for AAV9" was invented by Martin Lock (Southampton, Pa.) and Mauricio Alvira (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAA...