ALEXANDRIA, Va., June 6 -- United States Patent no. 12,282,028, issued on April 22, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Atomic description of immune complex that causes heparin-induced thrombocytopenia" was invented by Mark I. Greene (Penn Valley, Pa.), Douglas B. Cines (Wynnewood, Pa.), Zheng Cai (Wynnewood, Pa.) and Zhiqiang Zhu (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by...