US Patent Issued to The Trustees of Princeton University on Oct. 7 for "Cryptic antibiotics and methods for detecting bioactive cryptic metabolites" (New Jersey Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,436,145, issued on Oct. 7, was assigned to The Trustees of Princeton University (Princeton, N.J.).

"Cryptic antibiotics and methods for detecting bioactive cryptic metabolites" was invented by Mohammad R. Seyedsayamdost (Princeton, N.J.) and Kyuho Moon (Princeton, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of "silent" biosynthetic gene clusters. These clusters can be identified bioinformatically but are at best sparingly expressed under normal laboratory growth conditions; their products are therefore not interrogated during bioactivity screening ...