ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,384,993, issued on Aug. 12, was assigned to The Trustees of Indiana University (Bloomington, Ind.).

"Bioreactor" was invented by Lester Jeshua Smith (Maud, Texas), Brian Paul McCarthy (Indianapolis), Mark Robert Holland (McCordsville, Ind.) and Paul Richard Territo (Fishers, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing th...