US Patent Issued to The Scripps Research Institute on Oct. 21 for "Stabilized coronavirus spike (s) protein immunogens and related vaccines" (California Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,416, issued on Oct. 21, was assigned to The Scripps Research Institute (La Jolla, Calif.).

"Stabilized coronavirus spike (s) protein immunogens and related vaccines" was invented by Linling He (San Diego), Jiang Zhu (San Diego) and Ian A. Wilson (La Jolla, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequen...