US Patent Issued to THE ROCKEFELLER UNIVERSITY on April 22 for "Modified microorganisms expressing saga and related compositions for immunomodulation against infection and cancer immunotherapy" (New York, California Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,280,078, issued on April 22, was assigned to THE ROCKEFELLER UNIVERSITY (New York).

"Modified microorganisms expressing saga and related compositions for immunomodulation against infection and cancer immunotherapy" was invented by Howard Hang (Del Mar, Calif.) and Matthew Griffin (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compositions and methods based in part on the discovery that Enterococcus faecium secreted antigen A (SagA)-expressing bacteria are protective against enteric infections and enhances immune checkpoint inhibitor efficacy against cancer. Bacteria that express SagA or heterologous SagA, or orthologs thereof, are ...