US Patent Issued to The Research Foundation for The State University of New York on Oct. 7 for "Compositions and methods to block and bind CXCR4 to modulate cellular function" (New York Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,148, issued on Oct. 7, was assigned to The Research Foundation for The State University of New York (Amherst, N.Y.).

"Compositions and methods to block and bind CXCR4 to modulate cellular function" was invented by Juliane Nguyen (Buffalo, N.Y.) and Michael Deci (Amherst, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are composition comprising antibodies directed to the N-terminal domain of CXCR4. The antibody may be a scFv and can be fused to a RNA binding peptide. The fusion protein can be complexed to RNAi, such as micro RNA. The complexes can be used for targeting delivery of RNAi molecules to CXCR4 expressing cancer cells, as well ...