US Patent Issued to The Regents of the University of California on Aug. 12 for "CRY1-clock-BMAL1 complex-disrupting agents and methods of identifying and using same" (California Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,385,914, issued on Aug. 12, was assigned to The Regents of the University of California (Oakland, Calif.).

"CRY1-clock-BMAL1 complex-disrupting agents and methods of identifying and using same" was invented by Carrie Partch (Santa Cruz, Calif.), Alicia Michael (Santa Cruz, Calif.), Jennifer Fribourgh (Santa Cruz, Calif.) and Gian Carlo G. Parico (Santa Cruz, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are agents that disrupt CRY1-CLOCK-BMAL1 ternary complexes. In certain aspects, the agents bind to the secondary pocket of CRY1 and inhibit interaction between the secondary pocket and the PAS-B domain of CLOCK, to disrupt CRY1-CLOCK-BMA...