US Patent Issued to The Regents of the University of California on April 22 for "Treatment for restoring ureagenesis in carbamoyl phosphate synthetase 1 deficiency" (California Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,323, issued on April 22, was assigned to The Regents of the University of California (Oakland, Calif.).

"Treatment for restoring ureagenesis in carbamoyl phosphate synthetase 1 deficiency" was invented by Gerald Lipshutz (Los Angeles) and Matthew Nitzahn (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model...