US Patent Issued to The McLean Hospital on March 4 for "Methods for efficient generation of GABAergic interneurons from pluripotent stem cells" (New York Inventor)

ALEXANDRIA, Va., March 5 -- United States Patent no. 12,241,084, issued on March 4, was assigned to The McLean Hospital Corp. (Belmont, Mass.).

"Methods for efficient generation of GABAergic interneurons from pluripotent stem cells" was invented by Sangmi Chung (Ardsley, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Enhanced methods for the generation of medial ganglionic eminence (MGE) cells from pluripotent stem cells are provided that involve an additional step of contacting the cells with an activator of FGF8 signaling while differentiating Pax6+ cells progenitor cells into MGE cells with an activator of sonic hedgehog, and optionally a Wnt inhibitor. The activator of FGF8 signaling shifts the diff...