US Patent Issued to The Johns Hopkins University on Sept. 23 for "Induction of synthetic lethality with epigenetic therapy" (Maryland Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,419,900, issued on Sept. 23, was assigned to The Johns Hopkins University (Baltimore).

"Induction of synthetic lethality with epigenetic therapy" was invented by Srinivasan Yegnasubramanian (Baltimore), William G. Nelson (Baltimore), Ajay Vaghasia (Baltimore) and Philipp Nuhn (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed here...