US Patent Issued to The Johns Hopkins University on Oct. 21 for "Quantitative multiplex methylation specific PCR method-CMethDNA, reagents, and its use" (American, Malaysian Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,650, issued on Oct. 21, was assigned to The Johns Hopkins University (Baltimore).

"Quantitative multiplex methylation specific PCR method-CMethDNA, reagents, and its use" was invented by Saraswati Sukumar (Columbia, Md.), Mary Jo Fackler (Hunt Valley, Md.), Wei Wen Teo (Johor Bahru Johor, Malaysia), Zoila Areli Lopez Bujanda (Bethesda, Md.) and Antonio Wolff (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "A cMethDNA method quantitatively detects tumor DNA (or other circulating DNAs) in fluids such as serum or plasma at the lowest copy number. Unique compared to any other PCR-based assay, a small number of copies of a synthetic polynucleoti...