US Patent Issued to The Johns Hopkins University on May 13 for "Compositions and methods for targeted immunomodulatory antibodies and fusion proteins" (Maryland Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,295,968, issued on May 13, was assigned to The Johns Hopkins University (Baltimore).

"Compositions and methods for targeted immunomodulatory antibodies and fusion proteins" was invented by Atul Bedi (Timonium, Md.) and Rajani Ravi (Ruxton, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of...