US Patent Issued to The Johns Hopkins University on July 29 for "Bioreducible poly (beta-amino ester)s for siRNA delivery" (Maryland Inventors)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,522, issued on July 29, was assigned to The Johns Hopkins University (Baltimore).

"Bioreducible poly (beta-amino ester)s for siRNA delivery" was invented by Jordan J Green (Nottingham, Md.), Kristen Kozielski (Baltimore) and Stephany Yi Tzeng (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosoma...