US Patent Issued to The General Hospital on Nov. 4 for "Modified T cells and methods of their use" (Massachusetts Inventors)

ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,459,975, issued on Nov. 4, was assigned to The General Hospital Corp. (Boston).

"Modified T cells and methods of their use" was invented by Marcela V. Maus (Lexington, Mass.), Matthew Frigault (Somerville, Mass.) and Mark Cobbold (Winchester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides modified an isolated T lymphocytes having reduced or eliminated expression of the T Cell Receptor, due to reduced or eliminated expression of a CD3Zeta, T Cell Receptor Alpha Chain, or T Cell Receptor Beta Chain gene relative to a T lymphocyte without modification, where the isolated T lymphocyte expresses a protein comprising US6, UL40 vira...