US Patent Issued to The General Hospital on Nov. 18 for "Targeted t cells with cytotoxicity toward immunosuppressive cells" (Massachusetts Inventor)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,343, issued on Nov. 18, was assigned to The General Hospital Corp. (Boston).

"Targeted t cells with cytotoxicity toward immunosuppressive cells" was invented by Marcela Maus (Lexington, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are methods for producing and utilizing T cells comprising a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain specific for a target tumor antigen, and a polypeptide comprising an extracellular antigen binding domain specific for an extracellular polypeptide expressed on an immunosuppressive cell. The technology described herein is related to methods of treating can...